Chronic Hepatitis C Virus Infection

May 01, 2023
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This lesson focuses on defining, screening for, and diagnosing chronic HCV infection. Through history, physical examination, and laboratory (and other) testing. The lesson also covers identification of clinical manifestations of chronic HCV infection and its pathophysiology.

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References

  1. AASLD-IDSA. HCV Guidance: Recommendations for Testing, Managing, and Treating Hepatitis C. Available at: https://www.hcvguidelines.org/full-report/hcv-testing-and-linkage-care. Accessed 5/3/2023.
  2. Hepatitis C Online. Available at: https://www.hepatitisc.uw.edu/go/screening-diagnosis/recommendations-screening/core-concept/all. Updated August 30, 2016. Accessed 5/3/2023.
  3. Di Martino V, Rufat P, Boyer N, et al. The influence of human immunodeficiency virus coinfection on chronic hepatitis C in injection drug users: a long-term retrospective cohort study. Hepatology. 2001 Dec;34(6):1193-9.
  4. Graham CS, Baden LR, Yu E, et al. Influence of human immunodeficiency virus infection on the course of hepatitis C virus infection: a meta-analysis. Clin Infect Dis. 2001 Aug 15;33(4):562-9.
  5. De Lédinghen V, Barreiro P, Foucher J, et al. Liver fibrosis on account of chronic hepatitis C is more severe in HIV-positive than HIV-negative patients despite antiretroviral therapy. J Viral Hepat. 2008 Jun;15(6):427-33.
  6. Kirk GD, Mehta SH, Astemborski J, et al. HIV, age, and the severity of hepatitis C virus-related liver disease: a cohort study. Ann Intern Med. 2013 May 7;158(9):658-66.
  7. Fierer DS, Dieterich DT, Fiel MI, et al. Rapid progression to decompensated cirrhosis, liver transplant, and death in HIV-infected men after primary hepatitis C virus infection. Clin Infect Dis. 2013 Apr;56(7):1038-43.
  8. Cacoub P, Comarmoud C, Domont F, Savey L, Desbois AC, Saadoun D. Extrahepatic manifestations of chronic hepatitis C virus infection. Ther Adv Infect Dis. 2016 Feb;3(1):3-14.

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