National centers within the AETC Program serve unique roles within and beyond the AETC network.
- The National AETC Support Center works closely with the HRSA HIV/AIDS Bureau to coordinate cross-regional collaborative efforts. It manages this website, plans and executes the annual national Ryan White HIV/AIDS Program Clinical Conference, develops resources for clinical learners, provides technical assistance and communities of practice for AETC Program faculty and staff, and promotes the resources and services of the AETC Program.
- National Clinician Consultation Center manages the clinical hotline and warmlines for clinical professionals for consultation on HIV prevention, diagnosis, and treatment management; viral hepatitis; and substance use.